Título:	Effects of Panax ginseng extract in patients with fibromyalgia : a 12-week, randomized, double-blind, placebo-controlled trial
Autor(es):	Braz, Alessandra Sousa Morais, Liana Clébia S. Paula, Ana Patrícia de Diniz, Margareth F. F. M. Almeida, Reinaldo N.
Assunto:	Fibromialgia Ginseng Farmacologia Tratamento complementar Fitoterapia
Data de publicação:	Mar-2013
Editora:	Associação Brasileira de Psiquiatria - ABP
Referência:	BRAZ, Alessandra Sousa et al. Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial. Brazilian Journal of Psychiatry, São Paulo, v. 35, n. 1, p. 21-28, mar. 2013. DOI: http://dx.doi.org/10.1016/j.rbp.2013.01.004. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100005. Acesso em: 06 ago. 2020.
Abstract:	The purpose of the study was to evaluate the efficacy of an extract of Panax ginseng in patients with fibromyalgia. A randomized, double-blind, controlled clinical trial was carried out over 12 weeks to compare the effects of P. ginseng (100 mg/d) with amitriptyline (25 mg/d) and placebo in 38 patients with fibromyalgia: 13 in Group I (amitriptyline), 13 in Group II (placebo), and 12 in Group III (P. ginseng). Ratings on the Visual Analogue Scale (VAS) revealed a reduction in pain in the P. ginseng group (p < .0001), an improvement in fatigue (p < .0001) and an improvement in sleep (p < .001), with respect to baseline characteristics, but there were no differences between the three groups. With respect to anxiety, improvements occurred in the P. ginseng group compared to baseline (p < .0001); however, amitriptyline treatment resulted in significantly greater improvements (p < .05). P. ginseng reduced the number of tender points and improved patients' quality of life (using the Fibromyalgia Impact Questionnaire - FIQ); however, there were no differences between groups. The beneficial effects experienced by patients for all parameters suggest a need for further studies to be performed on the tolerability and efficacy of this phytotherapic as a complementary therapy for fibromyalgia.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Brazilian Journal of Psychiatry - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100005. Acesso em: 06 ago. 2020.
DOI:	https://dx.doi.org/10.1016/j.rbp.2013.01.004
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