Título:	The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats
Autor(es):	Durães, Leonardo de Castro Farias, Igor Eduardo Caetano de Morais, Pedro Henrique Alves de Oliveira, Paulo Gonçalves de Cavalcanti Neto, Florêncio Figueiredo Lino Junior, Ruy de Souza Feres, Omar Sousa, João Batista de
Assunto:	Pneumoperitônio Dióxido de carbono Anastomose Cicatrização de feridas Cólon (Anatomia) - cirurgia Ratos
Data de publicação:	2013
Editora:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Referência:	DURÃES, Leonardo de Castro et al. The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats. Acta Cirúrgica Brasileira, v. 28, n. 9, p. 670-677, 2013. DOI: https://doi.org/10.1590/S0102-86502013000900008. Disponível em: https://www.scielo.br/j/acb/a/d9SjmqRrTzFTFxFLGWR5Vhc/?lang=en#. Acesso em: 10 jul. 2021.
Abstract:	PURPOSE: To investigate the effects of pneumoperitoneum on colonic anastomosis healing. METHODS: Colonic anastomosis was performed in 120 rats divided into four groups: Group I - pneumoperitoneum before laparotomy, Group II - pneumoperitoneum after laparorrhaphy, Group III - pneumoperitoneum before laparotomy and after laparorrhaphy, Group IV - no pneumoperitoneum (control group). Pneumoperitoneum pressure was 5 mmHg. Animals were killed on the 3rd, 7th and 14th postoperative day. Hhistopathological features, anastomosis breaking strength, collagen histomorphometry and hydroxyproline concentration were assessed. RESULTS: Breaking strength between groups: (day 3, p=0.165; day 7, p=0.219; day 14, p=0.539). Histopathology revealed that group II had, on day 7, less infiltration of mononuclear cells (p=0.006), greater infiltration of polymorphonuclear cells (p=0.001) and greater necrosis (p=0.001); and on day 14, less fibrosis. Histomorphometry revealed a decrease in collagen in groups I and III (p<0.001) on day 7 and an increase in groups I and II on day 14 (p<0.001). Hydroxyproline concentration was similar for groups on days 3 (p=0.152), 7 (p=0.913) or 14 (p=0.981). CONCLUSION: Carbon dioxide does not impair the healing of colonic anastomosis in rats.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Acta Cirúrgica Brasileira - This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC). Fonte: https://www.scielo.br/j/acb/a/d9SjmqRrTzFTFxFLGWR5Vhc/?lang=en#. Acesso em: 10 jul. 2021.
DOI:	https://dx.doi.org/10.1590/S0102-86502013000900008
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