Título:	Brazilian clinical trial of uniform multidrug therapy for leprosy patients : the correlation between clinical disease types and adverse effects
Autor(es):	Gonçalves, Heitor de Sá Pontes, Maria Araci de Andrade Bührer-Sékula, Samira Cruz, Rossilene Almeida, Paulo Cesar Moraes, Maria Elisabete Amaral de Penna, Gerson Oliveira
Assunto:	Hanseníase Efeitos adversos Terapêutica
Data de publicação:	Dez-2012
Editora:	Instituto Oswaldo Cruz, Ministério da Saúde
Referência:	GONÇALVES, Heitor de Sá et al. Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, supl. 1, p. 74-78, dez. 2012. DOI: https://doi.org/10.1590/S0074-02762012000900013. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900013&lng=en&tlng=en. Acesso em: 22 out. 2020.
Abstract:	This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Memórias do Instituto Oswaldo Cruz - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900013&lng=en&tlng=en. Acesso em: 22 out. 2020.
DOI:	https://dx.doi.org/10.1590/S0074-02762012000900013
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