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Title: HLA in Brazilian Ashkenazic jews with chronic dermatophytosis caused by Trichophyton rubrum
Other Titles: Antígenos Leucocitários Humanos (HLA) em judeus Ashkenazitas brasileiros portadores de dermatofitose crônica causada por Trichophyton rubrum
Authors: Sadahiro, Aya
Moraes, José Roberto Feresin
Moraes, Maria Elisa Hue
Romero, Matilde
Gouvea, Nancy Alves de Lima
Gouvea, Celso José
Ogusku, Mauricio Morishi
Campbell, Iphis
Zaitz, Clarisse
Assunto:: Trichophyton rubrum
Antígenos de histocompatibilidade HLA
Issue Date: 2004
Publisher: Sociedade Brasileira de Microbiologia
Citation: SADAHIRO, Aya et al. HLA in Brazilian Ashkenazic Jews with chronic dermatophytosis caused by Trichophyton rubrum. Brazilian Journal of Microbiology, v. 35, n. 1-2, p. 69-73, 2004. DOI: https://doi.org/10.1590/S1517-83822004000100011. Disponível em: https://www.scielo.br/j/bjm/a/gG9TLNS8rTMMJvZSgbLnhYm/?lang=en#. Acesso em: 10 set. 2021.
Abstract: A freqüência dos HLA foi analisada em 25 Judeus Ashkenazitas, não consangüíneos, residentes em São Paulo, Brasil, com dermatofitose crônica causada por T. rubrum e em 25 indivíduos sadios, pertencentes ao mesmo grupo étnico dos pacientes. Observou-se valor estatisticamente significante (p<0,05) para HLA-B14 associado a resistência à dermatofitose crônica enquanto HLA-DQB1*06 (p=0,05) possivelmente relacionado a susceptibilidade. Estes achados indicam que o desenvolvimento da dermatofitose crônica pode ser influenciado por genes localizados no cromossomo 6, na região do complexo principal de histocompatibilidade.
Abstract: The frequency of HLA (Human Leucocyte Antigens) was analyzed in 25 non-consanguineous Brazilian Ashkenazic Jews, resident in the city of São Paulo, Brazil, suffering from chronic dermatophytosis caused by T. rubrum, and in 25 non-infected individuals belonging to the same ethnic group. Statistically significant values (p<0.05) were observed for HLA-B14 associated with resistance to chronic dermatophytosis and HLA-DQB1*06 (p=0.05) possibly related to susceptibility. These findings suggest that genes on the chromosome 6, in the region of the major histocompatibility complex, may influence the development of chronic dermatophytosis.
metadata.dc.description.unidade: Faculdade de Medicina (FMD)
Licença:: Brazilian Journal of Microbiology - This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC). Fonte: https://www.scielo.br/j/bjm/a/gG9TLNS8rTMMJvZSgbLnhYm/?lang=en#. Acesso em: 10 set. 2021.
DOI: https://dx.doi.org/10.1590/S1517-83822004000100011
Appears in Collections:Artigos publicados em periódicos e afins

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