Título:	Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing
Autor(es):	Jerônimo, Márcio Sousa Barros, Adria do Prado MoritaI, Vinícius Elord Zen Alves, Erika Oliveira Souza, Nathalia Lobão Barroso de Almeida, Rosane Mansan de Nóbrega, Yanna Karla de Medeiros Cavalcanti Neto, Florêncio Figueiredo Amorin, Rivadávio Fernandes Batista de Borin, Maria de Fátima Bocca, Anamélia Lorenzetti
Assunto:	Cicatrização de feridas Cirurgia Aminoácidos Testes
Data de publicação:	Set-2016
Editora:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Referência:	JERÔNIMO, Márcio Sousa et al. Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing. Acta Cirurgica Brasileira, v. 31, n. 9, p. 586-596, set. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000900586&lng=en&tlng=en>. Acesso em: 10 jul. 2017. doi: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000900586&lng=en&tlng=en.
Abstract:	PURPOSE: To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process. METHODS: L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration. RESULTS: Suggested that groups treated with L-arginine orally or topically improved wound repair when compared with non-treatad mice. L- arginine treatment stimulated TGF-β and restricted NO production leading to a mild Th1 response and collagen deposition in injured area, when it was orally administrated. Topical administration decreased IL-8 and CCR1 expression by wound cells but did not interfere with TNF-α and IL-10 production, ratifying the decrease of inflammatory response, the oral administration however, presented a higher iNOS and TGF-β expression then. L-arginine treatment also improved the improved the wound healing in immunosupressed or diabetic mice. CONCLUSION: L-arginine administrated orally or topically can be considered an important factor in the recuperation of tissues.
Licença:	Acta Cirurgica Brasileira - This is an open-access article distributed under the terms of the Creative Commons Attribution License (Attribution 4.0 International (CC BY 4.0)). Fonte: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000900586&lng=en&tlng=en>. Acesso em: 10 jul. 2017.
DOI:	https://dx.doi.org/10.1590/S0102-865020160090000003
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