Título:	Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys
Autor(es):	Saletti, Patrícia Grandizoli Maior, Rafael Plakoudi Souto Hori, Etsuro Nishijo, Hisao Tomaz, Carlos Alberto Bezerra
Assunto:	Esquizofrenia - tratamento Macaco
Data de publicação:	2-Set-2015
Editora:	Frontiers
Referência:	SALETTI, Patrícia Grandizoli et al. Sensorimotor gating impairments induced by MK-801 treatment may be reduced by tolerance effect and by familiarization in monkeys. Frontiers in Pharmacology, v. 6, Article 204, 2 set. 2015. Disponível em: <http://journal.frontiersin.org/article/10.3389/fphar.2015.00204/full>. Acesso em: 4 jul. 2017. doi: http://journal.frontiersin.org/article/10.3389/fphar.2015.00204/full.
Abstract:	Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate MK-801 effects on monkeys’ PPI, we tested eight capuchin monkeys (Sapajus spp.) using three different doses of MK-801 (0.01; 0.02; 0.03 mg/kg). Results show PPI impairment in acute administration of the highest dose (0.03 mg/kg). PPI impairment induced by MK-801 was reversed by re-exposure to the PPI test throughout treatment trials, in contrast with rodent studies. These results indicate that tolerance effect and familiarization with PPI test may reduce the sensorimotor gating deficits induced by MK-801 in monkeys, suggesting a drug-training interaction.
Licença:	Copyright © 2015 Saletti, Maior, Hori, Nishijo and Tomaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: <http://journal.frontiersin.org/article/10.3389/fphar.2015.00204/full>. Acesso em: 4 jul. 2017.
DOI:	https://dx.doi.org/10.3389/fphar.2015.00204
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