Título:	Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity : a case–control study
Autor(es):	Balsamo, Sandor Mota, Licia Maria Henrique da Carvalho, Jozélio Freire de Nascimento, Dahan da Cunha Tibana, Ramires Alsamir Santana, Frederico Santos de Moreno, Ricardo Lima Gualano, Bruno Santos Neto, Leopoldo Luiz dos
Assunto:	Aptidão física Lúpus eritematoso sistêmico Qualidade de vida Fadiga
Data de publicação:	8-Set-2013
Editora:	BioMed Central
Referência:	BALSAMO, Sandor et al. Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case–control study. BMC Musculoskeletal Disorders, v. 14, Article 263, 8 set. 2013. Disponível em: <https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-14-263>. Acesso em: 14 jun. 2017. doi: https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-14-263.
Abstract:	Background: The purpose of the present study was to compare dynamic muscle strength, functional performance, fatigue, and quality of life in premenopausal systemic lupus erythematosus (SLE) patients with low disease activity versus matched-healthy controls and to determine the association of dynamic muscle strength with fatigue, functional performance, and quality of life in SLE patients. Methods: We evaluated premenopausal (18–45 years) SLE patients with low disease activity (Systemic lupus erythematosus disease activity index [SLEDAI]: mean 1.5 ± 1.2). The control (n = 25) and patient (n = 25) groups were matched by age, physical characteristics, and the level of physical activities in daily life (International Physical Activity Questionnaire IPAQ). Both groups had not participated in regular exercise programs for at least six months prior to the study. Dynamic muscle strength was assessed by one-repetition maximum (1-RM) tests. Functional performance was assessed by the Timed Up and Go (TUG), in 30-s test a chair stand and arm curl using a 2-kg dumbbell and balance test, handgrip strength and a sit-and-reach flexibility test. Quality of life (SF-36) and fatigue were also measured. Results: The SLE patients showed significantly lower dynamic muscle strength in all exercises (leg press 25.63%, leg extension 11.19%, leg curl 15.71%, chest press 18.33%, lat pulldown 13.56%, 1-RM total load 18.12%, P < 0.001-0.02) compared to the controls. The SLE patients also had lower functional performance, greater fatigue and poorer quality of life. In addition, fatigue, SF-36 and functional performance accounted for 52% of the variance in dynamic muscle strength in the SLE patients. Conclusions: Premenopausal SLE patients with low disease activity showed lower dynamic muscle strength, along with increased fatigue, reduced functional performance, and poorer quality of life when compared to matched controls.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	© 2013 Balsamo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI:	https://dx.doi.org/10.1186/1471-2474-14-263
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