| Campo DC | Valor | Lengua/Idioma |
|---|
| dc.contributor.author | Jannuzzi, Grasielle Pereira | - |
| dc.contributor.author | Tavares, Aldo Henrique Fonseca Pacheco | - |
| dc.contributor.author | Kaihami, Gilberto Hideo | - |
| dc.contributor.author | Almeida, José Roberto Fogaça de | - |
| dc.contributor.author | Almeida, Sandro Rogério de | - |
| dc.contributor.author | Ferreira, Karen Spadari | - |
| dc.date.accessioned | 2017-06-26T15:19:54Z | - |
| dc.date.available | 2017-06-26T15:19:54Z | - |
| dc.date.issued | 2015-06-19 | - |
| dc.identifier.citation | JANNUZZI, Grasielle Pereira et al. ScFv from antibody that mimics gp43 modulates the cellular and humoral immune responses during Experimental Paracoccidioidomycosis. Plos One, v. 10, n. 6, Article e0129401, 19 jun. 2015. Disponível em: <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129401>. Acesso em: 14 jun. 2017. doi: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129401. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/23747 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Plos One | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | ScFv from antibody that mimics gp43 modulates the cellular and humoral immune responses during Experimental Paracoccidioidomycosis | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Micoses | pt_BR |
| dc.subject.keyword | Paracoccidioidomicose | pt_BR |
| dc.subject.keyword | Células | pt_BR |
| dc.rights.license | Copyright: © 2015 Jannuzzi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | pt_BR |
| dc.identifier.doi | https://dx.doi.org/10.1371/journal.pone.0129401 | pt_BR |
| dc.description.abstract1 | Paracoccidioidomycosis (PCM), caused by Paracoccidioides species is a prevalent systemic and progressive mycosis that occurs in Latin America. It is caused by Paracoccidioides species. Immunization with dendritic cells transfected with a plasmid encoding the scFv (pMAC/PS-scFv) that mimics the main antigen of P. brasiliensis (gp43) confers protection in experimental PCM. DCs link innate and adaptive immunity by recognizing invading pathogens and selecting the type of effector T cell to mediate the immune response. Here, we showed that DC-pMAC/PS-scFv induces the activation of CD4+ and CD8+ T cells. Moreover, our results demonstrated that BALB/c mice infected with P. brasiliensis and treated with DC-pMAC/PS-scFv showed the induction of specific IgG production against gp43 and IFN-γ, IL-12 and IL-4 cytokines. Analysis of regional lymph nodes revealed increases in the expression of clec7a, myd88, tlr2, gata3 and tbx21, which are involved in the immune response. Taken together, our results indicate that the scFv modulates the humoral and cellular immune responses and presents epitopes to CD4+ and CD8+ T cells. | pt_BR |
| Aparece en las colecciones: | Artigos publicados em periódicos e afins
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