Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks

Rodrigues, Anderson Messias; Teixeira, Marcus de Melo; Hoog, G. Sybren de; Schubach, Tânia Maria Pacheco; Pereira, Sandro Antonio; Fernandes, Geisa Ferreira; Bezerra, Leila Maria Lopes; Felipe, Maria Sueli Soares; Camargo, Zoilo Pires de

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Campo DC	Valor	Idioma
dc.contributor.author	Rodrigues, Anderson Messias	-
dc.contributor.author	Teixeira, Marcus de Melo	-
dc.contributor.author	Hoog, G. Sybren de	-
dc.contributor.author	Schubach, Tânia Maria Pacheco	-
dc.contributor.author	Pereira, Sandro Antonio	-
dc.contributor.author	Fernandes, Geisa Ferreira	-
dc.contributor.author	Bezerra, Leila Maria Lopes	-
dc.contributor.author	Felipe, Maria Sueli Soares	-
dc.contributor.author	Camargo, Zoilo Pires de	-
dc.date.accessioned	2017-06-23T11:59:48Z	-
dc.date.available	2017-06-23T11:59:48Z	-
dc.date.issued	2013-06-20	-
dc.identifier.citation	RODRIGUES, Anderson Messias et al. Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks. Plos Neglected Tropical Diseases, v. 7, n. 6, Article e2281, 20 jun. 2013. Disponível em: <http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002281>. Acesso em: 12 jun. 2017. doi: 10.1371/journal.pntd.0002281.	pt_BR
dc.identifier.uri	http://repositorio.unb.br/handle/10482/23725	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Plos One	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.title	Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Fungos - doenças	pt_BR
dc.subject.keyword	Gato	pt_BR
dc.subject.keyword	Diversidade genética	pt_BR
dc.subject.keyword	Epidemias	pt_BR
dc.rights.license	Copyright: 2013 Rodrigues et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.	pt_BR
dc.identifier.doi	https://dx.doi.org/10.1371/journal.pntd.0002281	pt_BR
dc.description.abstract1	Sporothrix schenckii, previously assumed to be the sole agent of human and animal sporotrichosis, is in fact a species complex. Recently recognized taxa include S. brasiliensis, S. globosa, S. mexicana, and S. luriei, in addition to S. schenckii sensu stricto. Over the last decades, large epidemics of sporotrichosis occurred in Brazil due to zoonotic transmission, and cats were pointed out as key susceptible hosts. In order to understand the eco-epidemiology of feline sporotrichosis and its role in human sporotrichosis a survey was conducted among symptomatic cats. Prevalence and phylogenetic relationships among feline Sporothrix species were investigated by reconstructing their phylogenetic origin using the calmodulin (CAL) and the translation elongation factor-1 alpha (EF1a) loci in strains originated from Rio de Janeiro (RJ, n = 15), Rio Grande do Sul (RS, n = 10), Parana´ (PR, n = 4), Sa˜o Paulo (SP, n = 3) and Minas Gerais (MG, n = 1). Our results showed that S. brasiliensis is highly prevalent among cats (96.9%) with sporotrichosis, while S. schenckii was identified only once. The genotype of Sporothrix from cats was found identical to S. brasiliensis from human sources confirming that the disease is transmitted by cats. Sporothrix brasiliensis presented low genetic diversity compared to its sister taxon S. schenckii. No evidence of recombination in S. brasiliensis was found by split decomposition or PHI-test analysis, suggesting that S. brasiliensis is a clonal species. Strains recovered in states SP, MG and PR share the genotype of the RJ outbreak, different from the RS clone. The occurrence of separate genotypes among strains indicated that the Brazilian S. brasiliensis epidemic has at least two distinct sources. We suggest that cats represent a major host and the main source of cat and human S. brasiliensis infections in Brazil.	pt_BR
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