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Título: Predictors of virologic failure in HIV/AIDS patients treated with highly active antiretroviral therapy in Brasília, Brazil during 2002–2008
Autor(es): Bello, Edson José Monteiro
Correia, Amabel Fernandes
Marins, José Ricardo Pio
Merchán-Hamann, Edgar
Kanzaki, Luis Isamu Barros
Assunto: AIDS (Doença)
Terapia antirretroviral
Brasília (DF)
Data de publicação: Nov-2011
Editora: Libertas Academica
Referência: BELLO, Edson José Monteiro. et al. Predictors of virologic failure in HIV/AIDS patients treated with highly active antiretroviral therapy in Brasília, Brazil during 2002–2008. Drug Target Insights, v. 5, p. 33-41, nov. 2011. Disponível em: <http://www.la-press.com/predictors-of-virologic-failure-in-hivaids-patients-treated-with-highl-article-a2925-abstract>. Acesso em: 5 jun. 2013.
Resumo: Little data exists concerning the efficacy of the antiretroviral therapy in the Federal District in Brazil, therefore in order to improve HIV/AIDS patients’ therapy and to pinpoint hot spots in the treatment, this research work was conducted. Of 139 HIV/AIDS patients submitted to the highly active antiretroviral therapy, 12.2% failed virologically. The significant associated factors related to unresponsiveness to the lentiviral treatment were: patients’ place of origin (OR = 3.28; IC95% = 1.0–9.73; P = 0.032) and Mycobacterium tuberculosis infection (RR = 2.90; IC95% = 1.19–7.02; P = 0.019). In the logistic regression analysis, the remaining variables in the model were: patients’ birthplace (OR = 3.28; IC95% = 1.10–9.73; P = 0.032) and tuberculosis comorbidity (OR = 3.82; IC95% = 1.19–12.22; P = 0.024). The patients enrolled in this survey had an 88.0% therapeutic success rate for the maximum period of one year of treatment, predicting that T CD4+ low values and elevated viral loads at pretreatment should be particularly considered in tuberculosis coinfection, besides the availability of new antiretroviral drugs displaying optimal activity both in viral suppression and immunological reconstitution.
Licença: Drug Target Insights - This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. Fonte: http://www.la-press.com/article.php?article_id=2925. Acesso em: 5 jun. 2013.
DOI: https://dx.doi.org/10.4137/DTI.S7527
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